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Top Five Canadian Online Casinos You Need to Check Out

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When it comes to selecting a grand online casino, you will find yourself bombarded with options and, frankly, a large percentage of players on the market and not worth your business.

So, how do you go about finding a trustworthy and enjoyable casino in the Canadian market? The truth is, it’s not easy. Ideally, you’d locate possible big-name brands that arouse your curiosity and then check out the many online reviews before finally selecting one that works.

In order to help you in your crusade, here are the brands that we feel are most rewarding in the online casino Canada industry. It’s worth noting that when selecting the best in the market, you should pay close attention to the following.

● Reputation
● Sign-Up Offers
Customer Service
● Payment Methods
● Range of Games

These aspects are the main points of interest that online casino users look out for before completing the sign-up process. They should be taken into account before you do likewise.

PlayOJO

These guys are one of the most popular in the business, especially in Canada, and their service is particularly appealing for those who like their casino action via mobile devices. As well as having a ton of games, Play OJO offers excellent welcome bonuses and has a great user interface that will keep you entertained for hours.

Royal Vegas

Royal Vegas is fabulous for slots and table games with over 700 games on offer and great live dealer options. It is perhaps their blackjack games that attract the most attention, with 35 variants and an excellent slick interface.

There are few casinos that have been around as long as Royal Vegas, which launched back in 2000, and the fact that they are still hugely popular goes some way to show you just how compelling and built for purpose their offering truly is.

Spin Galaxy

If you like spin action, then Spin Galaxy is the online casino for you. They have a truly astonishing number of spin games, including traditional favourites and those that are more modern leaning. They also offer some great movie tie-ins as well as other casino game options.

Bodog

Though Bodog is well known for its sports betting platform, its casino site is also top-rated in the Canadian market. Fronted by Rival Gaming and Real Time, Bodog has a very advanced setup, and their site is perhaps the freshest of those on our list. Bodog is keen to reward its loyal customers, offering ongoing promotions as well as solid sign-up offers for new users.

Mansion Casino

Mansion is one of the longest-running players in the casino market, and as such, they are one of the most trustworthy of those available. Powered by Playtech, Mansion’s casino site is very state-of-the-art and offers a vast selection of games. They offer a truly 24/7 customer service, which is more than most casinos can claim to have, and we are very impressed by their loyalty program, though be warned that access to this is by invitation only.

Todayville Content Team works with a wide variety of clients to develop compelling content solutions. Our experienced team develops strategic campaigns that use video and storytelling, digital advertising and social media to help our clients position and distinguish themselves in the market.

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How to Streamline Your Car Sales in Toronto? The Pointer for Car Sellers

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Many car owners doubt whether selling their property is worth the hassle they may face during sales. That’s reasonable because a car is not a small item, and you probably spent much on its purchase at some point and regularly invested in it to maintain it in good condition. Then, selling it for pennies is not your choice.

We went ahead and contacted Topcashforcars.ca, a company that is reputed for giving the highest cash prices for cars in Toronto. Their approach is straightforward and reduces hassle for sellers who want to sell their vehicles profitably without the complexities of dealing with customers.

Choosing the Right Counterparty Is a Key to Success

First, have you already decided where and to whom you can sell a vehicle? That’s your #1 thing to do. Typically, the choice is either selling autos to individuals who want to buy a second-market car to save some dollars or to specialized companies engaged in car buying. These companies are diverse enough and they often offer good conditions for a seller although their pricing is diverse too.

How can you get in touch with such buyers?

  • For individuals who buy second-hand vehicles, you can search on big Canadian bulletin boards online and sometimes, on social networks.
  • For the companies to deal with, Google is your best friend to ask for help. However, our consultants, Topcashforcars.ca also are among these buyers, so you can make it even easier and apply to them.

What is more beneficial for a car seller at this stage? We can surely say that dealing with car-buying companies considerably saves you time. The whole negotiation process can take a couple of hours, so you won’t wait long and remain under pressure of uncertainty. 

Making It Lighting-Fast Is Possible

The previous tip leads to another one: you can sell a car in a lighting-fast mode. Just do some easy preps like its examination at the service station to consider what price can you claim for it and clean it up. This takes no more than a day if you have a good service station in your neighborhood and it helps clearly understand the price and the condition of your car.

Then, you can ensure you set a real price by using special online calculators provided by the same car-buying companies. It may take just a couple of minutes and you’ll get a precise calculation based on your vehicle’s type, age, model, condition, and specific features. 

Getting Cash Instead of Bank Transfers or Checks Is Faster

One more thing you can do to sell your auto as fast as possible is to sell it for cash. Bank operations often take additional days to be processed. Thus, even if you are lucky enough to get in touch with a good buyer quickly, and even if you conclude a deal in a day or two, it’s not guaranteed that you get money to your bank account similarly quickly. Applying for cash transactions you avoid troubles with banks and extra commissions for the transaction too.

As you can see, selling a vehicle can be eating pears for you if you plan your sale and follow the tips we shared in this article.

If followed, these recommendations can allow you to easily sell your car and make a handsome return in the process. It is even more rewarding because time and energy has become invaluable and cash for cars, Toronto based companies and specifically Topcashforcars.ca, will ensure the vehicle is sold for the best price with little input from the owner. When selling a car, it is ideal to do enough research, plan and choose the right buyers so that the car selling process is fast and efficient.

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New frontiers in prostate cancer treatment with Actinium-225

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Prostate cancer is one of the most widespread malignant tumors in men. The pathology is successfully
treated in the first three stages, when the tumor can be removed or destroyed by radiation, but the disease at the metastatic stage becomes incurable. Surgery is usually not performed in such patients, and the main methods of treatment are hormonal and chemotherapy.

At a certain point this treatment stops working. 177Lu-PSMA-617 – Lutetium radiotargeted therapy,
becomes the next stage of treatment. A less common method of radiotargeted therapy is the treatment of prostate cancer with Actinium-225. It allows for a good outcome even in patients who have not responded to Lutetium therapy. In addition, the possibility of combined use of Actinium and Lutetium as part of tandem therapy is being investigated.

Principle of the method

Prostate cancer cells express a protein called prostate-specific membrane antigen (PSMA), which is not found in other tissues. PSMA is a target for the radiopharmaceutical. Once injected into the body, the drug accumulates only in tissues with high levels of PSMA because it binds to this protein. This results in a selective effect on the tumor and its metastases with minimal side effects.

Various radionuclides can be attached to ligands that target PSMA. The first such radionuclide was
Lutetium-177, which was synthesized in Germany in 2010, and its efficacy was first confirmed in trials in 2015. The good results were subsequently confirmed in a large study involving 13 university hospitals in Germany.

In recent years, Actinium-225 has been used instead of Lutetium. It destroys cancer cells with alpha
radiation.

Advantages and disadvantages of Actinium-225

Lutetium-177 is still considered the mainstay of radiotargeted therapy for castration-resistant prostate
cancer. However, Actinium is also used in certain situations, usually in patients with advanced cancer who have not responded to Lutetium treatment or when the efficacy of 177Lu-PSMA-617 has decreased after several courses (cancer progression has resumed).

Advantages of Actinium-225 over Lutetium-177:

● More pronounced effect due to alpha radiation causing double-strand breaks in DNA strands
● Less toxic effect on bone marrow and hematopoietic function due to shorter recovery time
● Works even in cases where the cancer is progressing against the background of Lutetium therapy

However, it is worth considering the disadvantages of this method:

● Limited evidence base compared to Lutetium
● Higher incidence of side effects, especially dry mouth

Who is a candidate for Actinium therapy

Radiotargeted therapy with Actinium is considered a novel treatment. The technique is indicated for
patients with metastatic castration-resistant prostate cancer (MCRPC) who:

● Have received Lutetium radiotargeted therapy but have not responded to it
● Have responded to Lutetium radiotargeted therapy, but have stopped responding after several
courses of treatment
● As part of tandem therapy: when Actinium and Lutetium are used in reduced doses

In summary, Actinium therapy is one of the last treatment options. It is used when chemotherapy, hormone therapy, radiotargeted therapy with Lutetium, and possibly targeted therapy (in the case of BRCA mutations, which occur in 28% of patients with metastatic prostate cancer) have already been tried. In addition, the choice of treatment tactics takes into account the location of the metastases. In the presence of predominantly bone metastases and pain syndrome, radionuclide therapy with Radium-223 is preferred, and in the presence of predominantly organ metastases, radiotargeted therapy with Lutetium or Actinium is performed.

If you want to undergo innovative treatment in Germany, visit Booking Health website. Our team will find a clinic for you and organize your trip.

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