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NHL trade rumours for December 2021
It’s been an exciting NHL season so far, though as you can see from some of the odds listed here, the breeze sure seems to be blowing against some of the Canadian teams right now. Let’s be realistic though: there are still several months before the trade deadline on March 21st, and any number of things could happen between now and the playoffs.
If you are currently unfamiliar with how to bet on the NHL from Canada, you may find it interesting that Canadian gamblers have it much easier in this regard than their America counterparts. We’ve listed the current Stanley Cup odds for each team to give you an idea of how the season is going – but a few good trades could still turn things around for any team on this list. Let’s Investigate!
Toronto Maple Leafs (+800)
Toronto sits just a few positions behind current favourites, the Colorado Avalanche as of the time of writing. With only one other team sitting between the Maple Leafs and Colorado, a large number of bets could easily sway this position, as could a particularly bad game on the ice for either the Avalanche, or the Vegas Golden Knights
Teams will be hoping to increase their Stanley Cup odds in the coming month.
In Toronto, defenseman Justin Holl has had a rough go recently and it seems the Leafs have their eye on Jakob Chychrun from Arizona.
Only time will tell if the numbers will continue swinging in the Leafs favour, or if the previously expected balance will be restored. We’ll have to wait until a little later in the season to know for sure.
Boston Bruins (+1,800) / Seattle Kraken (+20,000)
The Bruins General Manager Don Sweeney forms an important part of the Canadian men’s Olympic teams hierarchy in 2022. So far Sweeney seems to be doing an excellent job balancing his roles with the skill and finesse we’ve come to expect from such an accomplished and experienced general manager. Considering his fellow general manager Ron Francis over at the Kraken is also part of the same Olympic team, it’s easy to imagine these two talking trade on a regular basis in the coming months.
Don Sweeney’s thoughts regarding the Kraken’s Mason Appleton, 25, are well known. He believes the Bruins could save a little money in the final year of his contract. It’s not a huge number by NHL standards at just short of a million dollars and in a tight race one player could be enough to make a difference.
Ottawa Senators (+30,000)
The Senators have some tough choices to make right now – general manager Pierre Dorion needs to do something to try and fill the “gaping hole” left in the middle of the ice caused by long-term injuries to Colin White and Shane Pinto. If this were the only problem, a trade or two might just be enough to make a difference – but goaltending has also been shown to a be a problem this season and the lack of a truly effective defence mean that the Senators are, well … in a bit of a mess.
Can Dorion find a way to pull something out of the bag? Or will Ottawa fans be waiting until next season to see their team to return to their past form?
Montreal Canadiens (+40,000)
Those Moneyline odds won’t make great reading for any fan of the Canadiens. Something that has put pressure on their general manager to be looking at making a “full rebuild” of the team as soon as possible. They will need some luck in the NHL Draft Lottery – the Habs are really looking at moving out some big contracts including Jeff Petry and moving in #1 overall prospect Shane Wright to assist in this restructuring effort.
The trouble is, Petry is getting on a bit now (no disrespect meant there, Jeff!), and with three more years to run on a contract with a $6.25 million cap hit combined with less than stellar form on the ice so far this season, the Canadiens might struggle to gain as much benefit from letting Petry go as they may feel is necessary to make it a worthwhile option.
In Conclusion…
Expect to see a whole lot of crossed fingers at draft time – there are a lot of teams, particularly those North of the border, who could use more than a little help right now. But with a few fixes in just the right places, some of these teams could make formidable competition to the Avalanche’s domination of the odds so far in NHL 21/22.
Top 8 Stanley Cup Odds according to Unibet as of December 20, 2021
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How to Streamline Your Car Sales in Toronto? The Pointer for Car Sellers
Many car owners doubt whether selling their property is worth the hassle they may face during sales. That’s reasonable because a car is not a small item, and you probably spent much on its purchase at some point and regularly invested in it to maintain it in good condition. Then, selling it for pennies is not your choice.
We went ahead and contacted Topcashforcars.ca, a company that is reputed for giving the highest cash prices for cars in Toronto. Their approach is straightforward and reduces hassle for sellers who want to sell their vehicles profitably without the complexities of dealing with customers.
Choosing the Right Counterparty Is a Key to Success
First, have you already decided where and to whom you can sell a vehicle? That’s your #1 thing to do. Typically, the choice is either selling autos to individuals who want to buy a second-market car to save some dollars or to specialized companies engaged in car buying. These companies are diverse enough and they often offer good conditions for a seller although their pricing is diverse too.
How can you get in touch with such buyers?
- For individuals who buy second-hand vehicles, you can search on big Canadian bulletin boards online and sometimes, on social networks.
- For the companies to deal with, Google is your best friend to ask for help. However, our consultants, Topcashforcars.ca also are among these buyers, so you can make it even easier and apply to them.
What is more beneficial for a car seller at this stage? We can surely say that dealing with car-buying companies considerably saves you time. The whole negotiation process can take a couple of hours, so you won’t wait long and remain under pressure of uncertainty.
Making It Lighting-Fast Is Possible
The previous tip leads to another one: you can sell a car in a lighting-fast mode. Just do some easy preps like its examination at the service station to consider what price can you claim for it and clean it up. This takes no more than a day if you have a good service station in your neighborhood and it helps clearly understand the price and the condition of your car.
Then, you can ensure you set a real price by using special online calculators provided by the same car-buying companies. It may take just a couple of minutes and you’ll get a precise calculation based on your vehicle’s type, age, model, condition, and specific features.
Getting Cash Instead of Bank Transfers or Checks Is Faster
One more thing you can do to sell your auto as fast as possible is to sell it for cash. Bank operations often take additional days to be processed. Thus, even if you are lucky enough to get in touch with a good buyer quickly, and even if you conclude a deal in a day or two, it’s not guaranteed that you get money to your bank account similarly quickly. Applying for cash transactions you avoid troubles with banks and extra commissions for the transaction too.
As you can see, selling a vehicle can be eating pears for you if you plan your sale and follow the tips we shared in this article.
If followed, these recommendations can allow you to easily sell your car and make a handsome return in the process. It is even more rewarding because time and energy has become invaluable and cash for cars, Toronto based companies and specifically Topcashforcars.ca, will ensure the vehicle is sold for the best price with little input from the owner. When selling a car, it is ideal to do enough research, plan and choose the right buyers so that the car selling process is fast and efficient.
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New frontiers in prostate cancer treatment with Actinium-225
Prostate cancer is one of the most widespread malignant tumors in men. The pathology is successfully
treated in the first three stages, when the tumor can be removed or destroyed by radiation, but the disease at the metastatic stage becomes incurable. Surgery is usually not performed in such patients, and the main methods of treatment are hormonal and chemotherapy.
At a certain point this treatment stops working. 177Lu-PSMA-617 – Lutetium radiotargeted therapy,
becomes the next stage of treatment. A less common method of radiotargeted therapy is the treatment of prostate cancer with Actinium-225. It allows for a good outcome even in patients who have not responded to Lutetium therapy. In addition, the possibility of combined use of Actinium and Lutetium as part of tandem therapy is being investigated.
Principle of the method
Prostate cancer cells express a protein called prostate-specific membrane antigen (PSMA), which is not found in other tissues. PSMA is a target for the radiopharmaceutical. Once injected into the body, the drug accumulates only in tissues with high levels of PSMA because it binds to this protein. This results in a selective effect on the tumor and its metastases with minimal side effects.
Various radionuclides can be attached to ligands that target PSMA. The first such radionuclide was
Lutetium-177, which was synthesized in Germany in 2010, and its efficacy was first confirmed in trials in 2015. The good results were subsequently confirmed in a large study involving 13 university hospitals in Germany.
In recent years, Actinium-225 has been used instead of Lutetium. It destroys cancer cells with alpha
radiation.
Advantages and disadvantages of Actinium-225
Lutetium-177 is still considered the mainstay of radiotargeted therapy for castration-resistant prostate
cancer. However, Actinium is also used in certain situations, usually in patients with advanced cancer who have not responded to Lutetium treatment or when the efficacy of 177Lu-PSMA-617 has decreased after several courses (cancer progression has resumed).
Advantages of Actinium-225 over Lutetium-177:
● More pronounced effect due to alpha radiation causing double-strand breaks in DNA strands
● Less toxic effect on bone marrow and hematopoietic function due to shorter recovery time
● Works even in cases where the cancer is progressing against the background of Lutetium therapy
However, it is worth considering the disadvantages of this method:
● Limited evidence base compared to Lutetium
● Higher incidence of side effects, especially dry mouth
Who is a candidate for Actinium therapy
Radiotargeted therapy with Actinium is considered a novel treatment. The technique is indicated for
patients with metastatic castration-resistant prostate cancer (MCRPC) who:
● Have received Lutetium radiotargeted therapy but have not responded to it
● Have responded to Lutetium radiotargeted therapy, but have stopped responding after several
courses of treatment
● As part of tandem therapy: when Actinium and Lutetium are used in reduced doses
In summary, Actinium therapy is one of the last treatment options. It is used when chemotherapy, hormone therapy, radiotargeted therapy with Lutetium, and possibly targeted therapy (in the case of BRCA mutations, which occur in 28% of patients with metastatic prostate cancer) have already been tried. In addition, the choice of treatment tactics takes into account the location of the metastases. In the presence of predominantly bone metastases and pain syndrome, radionuclide therapy with Radium-223 is preferred, and in the presence of predominantly organ metastases, radiotargeted therapy with Lutetium or Actinium is performed.
If you want to undergo innovative treatment in Germany, visit Booking Health website. Our team will find a clinic for you and organize your trip.
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