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New frontiers in prostate cancer treatment with Actinium-225

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Prostate cancer is one of the most widespread malignant tumors in men. The pathology is successfully
treated in the first three stages, when the tumor can be removed or destroyed by radiation, but the disease at the metastatic stage becomes incurable. Surgery is usually not performed in such patients, and the main methods of treatment are hormonal and chemotherapy.

At a certain point this treatment stops working. 177Lu-PSMA-617 – Lutetium radiotargeted therapy,
becomes the next stage of treatment. A less common method of radiotargeted therapy is the treatment of prostate cancer with Actinium-225. It allows for a good outcome even in patients who have not responded to Lutetium therapy. In addition, the possibility of combined use of Actinium and Lutetium as part of tandem therapy is being investigated.

Principle of the method

Prostate cancer cells express a protein called prostate-specific membrane antigen (PSMA), which is not found in other tissues. PSMA is a target for the radiopharmaceutical. Once injected into the body, the drug accumulates only in tissues with high levels of PSMA because it binds to this protein. This results in a selective effect on the tumor and its metastases with minimal side effects.

Various radionuclides can be attached to ligands that target PSMA. The first such radionuclide was
Lutetium-177, which was synthesized in Germany in 2010, and its efficacy was first confirmed in trials in 2015. The good results were subsequently confirmed in a large study involving 13 university hospitals in Germany.

In recent years, Actinium-225 has been used instead of Lutetium. It destroys cancer cells with alpha
radiation.

Advantages and disadvantages of Actinium-225

Lutetium-177 is still considered the mainstay of radiotargeted therapy for castration-resistant prostate
cancer. However, Actinium is also used in certain situations, usually in patients with advanced cancer who have not responded to Lutetium treatment or when the efficacy of 177Lu-PSMA-617 has decreased after several courses (cancer progression has resumed).

Advantages of Actinium-225 over Lutetium-177:

● More pronounced effect due to alpha radiation causing double-strand breaks in DNA strands
● Less toxic effect on bone marrow and hematopoietic function due to shorter recovery time
● Works even in cases where the cancer is progressing against the background of Lutetium therapy

However, it is worth considering the disadvantages of this method:

● Limited evidence base compared to Lutetium
● Higher incidence of side effects, especially dry mouth

Who is a candidate for Actinium therapy

Radiotargeted therapy with Actinium is considered a novel treatment. The technique is indicated for
patients with metastatic castration-resistant prostate cancer (MCRPC) who:

● Have received Lutetium radiotargeted therapy but have not responded to it
● Have responded to Lutetium radiotargeted therapy, but have stopped responding after several
courses of treatment
● As part of tandem therapy: when Actinium and Lutetium are used in reduced doses

In summary, Actinium therapy is one of the last treatment options. It is used when chemotherapy, hormone therapy, radiotargeted therapy with Lutetium, and possibly targeted therapy (in the case of BRCA mutations, which occur in 28% of patients with metastatic prostate cancer) have already been tried. In addition, the choice of treatment tactics takes into account the location of the metastases. In the presence of predominantly bone metastases and pain syndrome, radionuclide therapy with Radium-223 is preferred, and in the presence of predominantly organ metastases, radiotargeted therapy with Lutetium or Actinium is performed.

If you want to undergo innovative treatment in Germany, visit Booking Health website. Our team will find a clinic for you and organize your trip.

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From Innovation Hubs to Digital Habits, How Work and Leisure Are Changing in Alberta

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Things have been changing in Alberta. The province isn’t just about oil and cattle anymore. Along with the wide-open skies, there’s a growing sense of invention. Just taking a walk through Calgary or Edmonton, you can see a difference from a few years ago. You’ll see people tapping away on laptops in coffee shops and talking about new ideas. 

The workplace also looks completely different compared to a few years ago. Times have changed, with people being able to work from home, coffee shops, or any remote setting. Boring old offices have changed into relaxed lounges and coffee corners, which help to inspire creativity. Instead of traditional classrooms, learners can now do a lot of their lessons online. 

But it’s not all about work. How people relax and unwind has also changed. Streaming their favourite show, gaming, and online entertainment have definitely become a part of everyday life. When the weather gets too cold or the schedule becomes too busy, entertainment is just a click away.

Online gaming has grown into a favorite digital pastime. Much like the best online casinos in the country, the fun comes from having variety. Some players chase the excitement of high-stakes games, while others prefer slower, social ones that let them chat with friends. There are games to suit every style and mood. There are also great incentives to look out for, like huge welcome bonuses, free spins, and VIP and loyalty points (source: https://www.pokerstrategy.com/online-casinos/canada/). These are especially great if you play regularly. 

This trend of enjoying digital downtime also connects with Alberta’s working culture. The same traits that make Albertans great at building and problem-solving also show up in how they play. Whether they’re testing a new game feature, trying out a bonus offer, or experimenting with different apps, it’s all about curiosity. This habit of trying, learning, and adjusting is shaping a generation that’s both playful and ambitious. They treat technology as a tool for creativity and connection.

You can see this mix of work and leisure in everyday life. Someone might take a break from a remote work project to stream a show and then go right back to brainstorming ideas with colleagues. The old ways of separating work and play have changed. While people work just as hard, they’re finding new ways to relax and recharge. Young professionals are creating lifestyles that value flexibility as well as personal balance.

Alberta’s economy has always been resilient, but having this new digital layer has added something new. Ideas, skills, and online habits are becoming the province’s newest source of energy.

This wave of change matters because it’s not limited to one industry or age group. It’s happening in living rooms, classrooms, and working spaces. Alberta’s people are showing that progress can begin anywhere you open a laptop or pick up a phone. Innovation is not just about inventing something new. It’s about how everyday choices include blending the digital world into the real world. Alberta still holds onto its hardworking roots, but now it’s combined that with imagination and digital confidence. This is helping to shape a future that is full of possibilities.

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Cryptocurrency and Online Casinos and What’s Next for Bitcoin and Ethereum Payments: Overview From Specialists at Rabona Betting

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Cryptocurrencies are becoming more common in everyday transactions. You can purchase things via digital currency on different sites and the system automatically exchanges it into the fiat currency like CAD.

This payment method is also popular at online casinos because of fast transactions, specifically, withdrawals. You can deposit money and place a bet on Napoli FC Rabona Canada, play various games, and then withdraw winnings the way you deposited funds. This article explores this interesting opportunity and what may come in the future.

Why Casinos Use Cryptocurrency

Online casinos like Rabona betting use cryptocurrency because it transfers funds faster than traditional payment systems. Bitcoin and Ethereum transactions don’t rely on banks, so transfers complete within minutes.

Players from countries with financial regulations use crypto wallets to send or receive funds without card rejections or blocked transfers. Casinos also cut costs since they don’t pay high processing fees to banks or card companies.

Crypto systems record each transaction on a blockchain ledger, so every move of money is visible and cannot be changed. That reduces disputes over withdrawals and deposits since each transaction’s info is available in public records.

Casinos that accept Bitcoin or Ethereum attract a wide range of players who prefer anonymity. Traditional payment systems require full identity checks, while crypto transfers use wallet addresses.

Players still need to pass KYC checks under legal standards, but crypto wallets give more privacy since they don’t require your bank data.

How Bitcoin and Ethereum Shape Casino Payments

Bitcoin is the top choice for online gamblers because most payment systems already integrate it easily. It allows deposits and withdrawals in similar amounts to bank transfers.

Sites like Rabona betting often provide it for high-volume transactions because cryptocurrency networks handle large sums safely and quickly. Digital currencies stands out because they allow smart contracts.

These contracts handle payouts automatically when a condition is met. For example, a casino game that uses an Ethereum contract can send a payout as soon as a winning combination appears, without manual approval.

Players deposit money and the casino automatically exchanges it to CAD. Thus, users can play bets in a currency they’re used to, and withdraw via the same crypto system that converts CAD to BTC, ETH, etc.

What’s Next for Bitcoin and Ethereum in Gambling

Future development aims to increase transaction speed and reduce fees. Bitcoin developers work on the Lightning Network, which processes microtransactions instantly through off-chain channels. That system suits online casinos since it handles many small bets quickly.

Ethereum’s developers improve scalability through updates that raise network capacity and lower gas costs. That’s one of the reasons why Ethereum switched from PoW to PoS.

Conclusion

Casinos like Rabona betting and others keep expanding payments to include more currencies like Solana, Cardano, Avalanche, or stablecoins like USDC, EURC, EURQ, and more. Most cryptocurrencies process transactions faster and provide some sort of anonymity, so players will continue using them at online casinos.

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