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How the Online Gambling Industry is Helping the Global Economy

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Even before society started ushering in the digital age of human connectivity and productivity, the gambling sector has long been one of the biggest fixtures of the global economy. In many governments all around the world, the local gambling economy has accounted for millions of dollars in revenues that have been translated into additional government taxes and charitable profits.

Lately, the casino industry has been undergoing something of a seismic shift in terms of how gamblers are playing their favourite casino games. In the past, people would have to travel to the nearest or most accessible land-based casinos before they could start placing their bets. These days, it’s all a matter of hopping online via one’s PC or smartphone to access online gambling platforms scattered all around the globe.

This added layer of accessibility and convenience for the casino industry has resulted in the propagation of more gamblers than there have ever been in the past. In all corners of the world, people are engaging in online gambling activities at a rate that has never been seen before. As it stands, the industry is performing at an all-time high and experts predict that the growth of the industry will continue to soar as technology becomes more sophisticated and as high-speed internet becomes more accessible to more sectors of the consumer public.

Given the meteoric rise of the online gambling industry, many governments all over the world are now scrambling to update existing laws and regulations surrounding online gambling activity. This is because governments are now more incentivized to regulate gambling activity. There are far too many taxation opportunities at stake for governments to merely ignore the bustling gambling industry. Aside from that, studies have shown that rampant gambling is still
taking place even in areas of the world where gambling is supposedly outlawed or unregulated.

Of course, some countries will take a more lenient approach to taxing their citizens. For example, in Canada, there are no taxes for recreational players who engage in online gambling. This means that citizens of Canada are free to take home their winnings from any gambling platform. These more consumer-friendly gambling laws have resulted in Canadians being one of the most active gambling populations in the world. One can merely hop on the internet and find the best online casino in Canada for them because of how populous these sites are.

Just across the Atlantic in European countries, the gambling industry is estimated to be worth approximately $53 billion. Experts even say that the industry is expected to reach a growth rate of 11.5% until 2027, skyrocketing its overall value to well over $100 billion. As may be expected, this regulated gambling activity results in taxable revenues. Aside from that, unlike Canada, most gambling winnings in Europe are taxable. So, the government is essentially getting profits from both the consumers and service providers alike.

But there are other aspects of the global economy that are greatly benefiting from the rise of online gambling. In particular, the fields of software development, software licensing, and website hosting are also experiencing extreme boosts from the industry.

Since the online gambling market is growing to become more and more competitive, new casino websites are sprouting up almost every month in order to cater to the increasing demand. This means that software development companies are raking in the revenues from licensing fees. Aside from that, many license-granting bodies around the world are also benefitting from online gambling operations being established.

The overhead expenses that come with setting up and running an online casino are far less costly and less risky than those that are associated with setting up an actual casino. This means that operators can maximize margins and further stimulate the online gambling industry to stir the market.

Online gambling is currently at an all-time high, and there are no reasons to expect that the industry is going to slow down or regress anytime soon. In fact, trends seem to dictate that the industry is cementing itself as a formidable force in the global economy and it will stay that way for the foreseeable future.

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How to Streamline Your Car Sales in Toronto? The Pointer for Car Sellers

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Many car owners doubt whether selling their property is worth the hassle they may face during sales. That’s reasonable because a car is not a small item, and you probably spent much on its purchase at some point and regularly invested in it to maintain it in good condition. Then, selling it for pennies is not your choice.

We went ahead and contacted Topcashforcars.ca, a company that is reputed for giving the highest cash prices for cars in Toronto. Their approach is straightforward and reduces hassle for sellers who want to sell their vehicles profitably without the complexities of dealing with customers.

Choosing the Right Counterparty Is a Key to Success

First, have you already decided where and to whom you can sell a vehicle? That’s your #1 thing to do. Typically, the choice is either selling autos to individuals who want to buy a second-market car to save some dollars or to specialized companies engaged in car buying. These companies are diverse enough and they often offer good conditions for a seller although their pricing is diverse too.

How can you get in touch with such buyers?

  • For individuals who buy second-hand vehicles, you can search on big Canadian bulletin boards online and sometimes, on social networks.
  • For the companies to deal with, Google is your best friend to ask for help. However, our consultants, Topcashforcars.ca also are among these buyers, so you can make it even easier and apply to them.

What is more beneficial for a car seller at this stage? We can surely say that dealing with car-buying companies considerably saves you time. The whole negotiation process can take a couple of hours, so you won’t wait long and remain under pressure of uncertainty. 

Making It Lighting-Fast Is Possible

The previous tip leads to another one: you can sell a car in a lighting-fast mode. Just do some easy preps like its examination at the service station to consider what price can you claim for it and clean it up. This takes no more than a day if you have a good service station in your neighborhood and it helps clearly understand the price and the condition of your car.

Then, you can ensure you set a real price by using special online calculators provided by the same car-buying companies. It may take just a couple of minutes and you’ll get a precise calculation based on your vehicle’s type, age, model, condition, and specific features. 

Getting Cash Instead of Bank Transfers or Checks Is Faster

One more thing you can do to sell your auto as fast as possible is to sell it for cash. Bank operations often take additional days to be processed. Thus, even if you are lucky enough to get in touch with a good buyer quickly, and even if you conclude a deal in a day or two, it’s not guaranteed that you get money to your bank account similarly quickly. Applying for cash transactions you avoid troubles with banks and extra commissions for the transaction too.

As you can see, selling a vehicle can be eating pears for you if you plan your sale and follow the tips we shared in this article.

If followed, these recommendations can allow you to easily sell your car and make a handsome return in the process. It is even more rewarding because time and energy has become invaluable and cash for cars, Toronto based companies and specifically Topcashforcars.ca, will ensure the vehicle is sold for the best price with little input from the owner. When selling a car, it is ideal to do enough research, plan and choose the right buyers so that the car selling process is fast and efficient.

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New frontiers in prostate cancer treatment with Actinium-225

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Prostate cancer is one of the most widespread malignant tumors in men. The pathology is successfully
treated in the first three stages, when the tumor can be removed or destroyed by radiation, but the disease at the metastatic stage becomes incurable. Surgery is usually not performed in such patients, and the main methods of treatment are hormonal and chemotherapy.

At a certain point this treatment stops working. 177Lu-PSMA-617 – Lutetium radiotargeted therapy,
becomes the next stage of treatment. A less common method of radiotargeted therapy is the treatment of prostate cancer with Actinium-225. It allows for a good outcome even in patients who have not responded to Lutetium therapy. In addition, the possibility of combined use of Actinium and Lutetium as part of tandem therapy is being investigated.

Principle of the method

Prostate cancer cells express a protein called prostate-specific membrane antigen (PSMA), which is not found in other tissues. PSMA is a target for the radiopharmaceutical. Once injected into the body, the drug accumulates only in tissues with high levels of PSMA because it binds to this protein. This results in a selective effect on the tumor and its metastases with minimal side effects.

Various radionuclides can be attached to ligands that target PSMA. The first such radionuclide was
Lutetium-177, which was synthesized in Germany in 2010, and its efficacy was first confirmed in trials in 2015. The good results were subsequently confirmed in a large study involving 13 university hospitals in Germany.

In recent years, Actinium-225 has been used instead of Lutetium. It destroys cancer cells with alpha
radiation.

Advantages and disadvantages of Actinium-225

Lutetium-177 is still considered the mainstay of radiotargeted therapy for castration-resistant prostate
cancer. However, Actinium is also used in certain situations, usually in patients with advanced cancer who have not responded to Lutetium treatment or when the efficacy of 177Lu-PSMA-617 has decreased after several courses (cancer progression has resumed).

Advantages of Actinium-225 over Lutetium-177:

● More pronounced effect due to alpha radiation causing double-strand breaks in DNA strands
● Less toxic effect on bone marrow and hematopoietic function due to shorter recovery time
● Works even in cases where the cancer is progressing against the background of Lutetium therapy

However, it is worth considering the disadvantages of this method:

● Limited evidence base compared to Lutetium
● Higher incidence of side effects, especially dry mouth

Who is a candidate for Actinium therapy

Radiotargeted therapy with Actinium is considered a novel treatment. The technique is indicated for
patients with metastatic castration-resistant prostate cancer (MCRPC) who:

● Have received Lutetium radiotargeted therapy but have not responded to it
● Have responded to Lutetium radiotargeted therapy, but have stopped responding after several
courses of treatment
● As part of tandem therapy: when Actinium and Lutetium are used in reduced doses

In summary, Actinium therapy is one of the last treatment options. It is used when chemotherapy, hormone therapy, radiotargeted therapy with Lutetium, and possibly targeted therapy (in the case of BRCA mutations, which occur in 28% of patients with metastatic prostate cancer) have already been tried. In addition, the choice of treatment tactics takes into account the location of the metastases. In the presence of predominantly bone metastases and pain syndrome, radionuclide therapy with Radium-223 is preferred, and in the presence of predominantly organ metastases, radiotargeted therapy with Lutetium or Actinium is performed.

If you want to undergo innovative treatment in Germany, visit Booking Health website. Our team will find a clinic for you and organize your trip.

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