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Actor’s Death Raises Alarm about Off-Label Anesthetic

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From Heartland Daily News

By  Kevin Stone Kevin Stone

A federal court has indicted and charged five individuals for contributing to the death of actor Matthew Perry by providing him with the anesthetic ketamine.

On October 28, 2023, Perry was found floating face-down in his hot tub. An autopsy later revealed his death had been caused by “acute effects of ketamine.” Perry, a star of the television show Friends, had long struggled with addiction.

Charged in the 18-count indictment are Perry’s personal assistant, Kenneth Iwamasa; two doctors, Salvador Plasencia and Mark Chavez; and two other individuals, Erik Fleming and Jasveen Sangha. Sangha was known as the “Ketamine Queen” who is accused of running a North Hollywood “stash house.”

Multiple Players Charged

Documents filed by prosecutors claim Perry’s assistant and an acquaintance worked with the two doctors and the drug dealer to provide tens of thousands of dollars worth of ketamine to fuel Perry’s addiction. Fleming coordinated the sale with Sangha, prosecutors say.

Iwamasa provided at least 27 ketamine injections to Perry in the five days leading up to his death, according to the prosecution. Chavez admitted selling ketamine to Plasencia for redistribution to Perry by falsifying information to a distributor and then using a prescription written in the name of a former patient.

When Plasencia texted another doctor about how much to charge Perry for the ketamine, he wrote, “I wonder how much this moron will pay,” and “Let’s find out,” prosecutors say. The trial date for Chavez and Plasencia is set for March 4, 2025.

Binge-Use Temptation

Ketamine is a dissociative anesthetic that can produce hallucinogenic effects. Ketamine is also used as a pain reliever and for the relief of treatment-resistant depression.

Some people use ketamine as a recreational drug for its ability to induce hallucinations. The effects of ketamine are short-lived, and users may rapidly develop tolerance to the drug, leading some to binge-use it.

Celebrity Power, Vulnerability

Ketamine is widely accepted as safe and effective for use as an anesthetic in a clinical setting. Off-label uses of the drug that may lead to abuse have led to rising concerns.

A recent New York Times article questioned the drug’s safety for off-label use in the wake of Perry’s death. Although ketamine ordinarily carries no more risk than other anesthetics, pain relievers, and antidepressants.

Celebrities can use their fame and wealth to circumvent effective safeguards against over-prescription and abuse, says Devon Herrick, a health economist.

“Physicians have significant leeway to prescribe FDA-approved medications off-label,” said Herrick. “Some off-label therapies later become mainstream, while others fall out of favor. What makes Matthew Perry’s situation unique was his celebrity status. Similar to the experience of Michael Jackson, Perry was able to enlist the help of physicians willing to provide him with a risky drug therapy not appropriately monitored.

“It’s unlikely a noncelebrity patient would be able to find a doctor willing to administer an anesthetic in their home,” said Herrick. “The lure of both money and bragging rights to say they’re a celebrity doctor likely culminated in Perry’s demise.”

Off-Label Benefits

Ketamine was developed as an anesthetic agent and was found to help treat some mental health conditions through off-label use, which is a common procedure, says Jeffrey Singer, a senior fellow at the Cato Institute who defends off-label use of the drug.

“Roughly 20 percent of all drugs prescribed in the U.S. are for off-label uses,” said Singer. “The [Food and Drug Administration, FDA] has always deferred to clinicians and clinical researchers on how to use drugs off-label. Once the FDA approves a drug for a particular indication, it permits clinicians to use it for any other indication where clinicians and clinical researchers believe the drug can be helpful.”

This real-world experience brings important knowledge, says Singer.

“As clinical research and clinical experience continue, such off-label drug use can lead to subsequent therapeutic advances,” said Singer. “However, clinical researchers often discover over time that specific off-label uses do not work. Over time, we should learn a lot more about what conditions ketamine works best for and what are the optimal ways to use it for those conditions.”

The system is working, says Singer.

“There is no reason why the FDA should add to the already cumbersome regulatory regime by requiring further approvals for off-label uses,” said Singer. “The FDA should leave the off-label uses of drugs to clinical researchers, clinicians, and the civil tort system.”

Black Market Problem

Adding new legal barriers to ketamine prescription would probably drive those wishing to abuse the drug into the black market, where its use would be wholly unmonitored and more dangerous drugs are also readily available, says Singer.

“People are already getting ketamine in the black market, along with other psychedelics such as MDMA, psilocybin, DMT, and magic mushrooms,” said Singer. “If the FDA further restricted online sales [of ketamine], it would only intensify profits in the black market and drive people to the black market, where the purity and strength of these drugs are less certain.

“We already have seen reports of black market MDMA—“ecstasy” or “Molly”—being laced with fentanyl,” said Singer. “Further restricting online sales of ketamine—or limiting its off-label use by licensed clinicians—will only make it more dangerous for people who continue to use ketamine. But it will not prevent them from using it.”

Kevin Stone ([email protected]writes from Arlington, Texas.

 

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Crime

Cartel threats against border agents include explosives, drones

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MXM logo MxM News

Quick Hit:

Cartels are intensifying their threats against U.S. Border Patrol and ICE agents, employing increasingly sophisticated tactics, including drones, wireless tracking devices, and potential explosive attacks. As President Donald Trump strengthens border security measures, agents face growing dangers both at and beyond the southern border. Experts warn that these threats are an effort to counteract the administration’s immigration enforcement policies.

Key Details:

  • Cartels are using drones and wireless tracking to monitor and potentially attack Border Patrol and ICE agents.
  • The discovery of a security risk tied to body cameras has led CBP to suspend their use to prevent agents from being tracked.
  • Leaks of ICE raids pose additional threats, increasing the risk of ambushes against agents conducting enforcement operations.

Diving Deeper:

Cartels along the U.S.-Mexico border are becoming more aggressive as President Trump enforces stricter immigration policies, with reports indicating that border agents are facing an escalating range of security threats. Fox News reports that Mexican cartels are leveraging new technology to track and potentially harm Customs and Border Protection (CBP) and Immigration and Customs Enforcement (ICE) agents.

Lora Ries, director of the Heritage Foundation’s Border Security and Immigration Center, emphasized that cartels are feeling the pressure from Trump’s border policies and are resorting to dangerous countermeasures. “The cartels are losing business. The encounters at the border are the lowest they’ve been in decades, and the cartels are not just going to give up that business quietly,” Ries told Fox News.

Among the threats agents face are drones used for surveillance, gunfire from across the border, and even the possibility of improvised explosive devices (IEDs). A recent internal memo warned that cartels might be planning to use snipers positioned in Mexico to attack U.S. agents. Additionally, agents are now vulnerable to tracking through wireless technology, prompting CBP to suspend the use of body-worn cameras after a social media post revealed they could be exploited via Bluetooth scanning apps.

The suspension of body cameras has raised concerns about increased false claims against border agents. Ries warned that “the number of claims of abuse are about to jump to exploit this lack of camera use,” underscoring the challenges agents will face without recorded footage of their encounters.

Beyond external threats from cartels, agents must also contend with internal security risks. Leaks about upcoming ICE raids have made enforcement operations more dangerous, potentially exposing agents to ambushes. Ries noted, “That subjects ICE agents to an ambush… Worse would be if aliens stay here and attack ICE agents, that is a risk.”

To counter these threats, border security experts stress the need for increased congressional funding to provide CBP and ICE agents with enhanced technology, equipment, and manpower. Ries urged lawmakers to act swiftly, stating, “Congress needs to hurry up” to ensure agents have the necessary resources to carry out Trump’s mass deportation efforts and secure the southern border.

As cartels escalate their tactics in response to Trump’s immigration policies, the safety of border agents remains a growing concern, highlighting the urgent need for stronger enforcement and security measures.

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Crime

Why is Trump threatening Canada? The situation is far worse than you think!

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From LifeSiteNews

By Frank Wright

Multiple reports are proving that Donald Trump’s claims that Canada’s lax approach to fentanyl poses a grave threat is even worse than the U.S. president has stated.

(LifeSiteNews) — A report from the Dana Cambole Show gives a sensational explanation on why U.S. President Donald Trump seems to have Canada in his sights. Her guest on the ITM Trading Channel is the Canadian investigative journalist Samuel Cooper, who says: “Canada has become a node of Chinese infiltration and organized crime activity – especially in Vancouver.”

His bold claim buttresses the accusations made by Trump that the U.S. faces a crisis on its northern border. On February 1, Trump issued an executive order titled, “Imposing Duties to Arrest the Flow of Illicit Drugs Across Our Northern Border” 

In it, Trump said his measures to impose punishing trade tariffs were to address the “challenges” presented by the “Gang members, smugglers, human traffickers, and illicit drugs of all kinds [which] have poured across our borders and into our communities.” 

He said the Canadian government had failed in its duty to address these issues. 

“Canada has played a central role in these challenges, including by failing to devote sufficient attention and resources or meaningfully coordinate with United States law enforcement partners to effectively stem the tide of illicit drugs.” 

Is Trump ‘invading’ Canada?

These bold claims have been interpreted as a means of dictating to – or even “annexing” Canada. This has “soured relations” with Canadians, as the Chinese Toronto-based journalist Kevin Jiang reports. 

Some critics argue Trump is not serious about fentanyl or crime, and is simply undermining Canadian sovereignty and even threatening to “invade” Canada.   

So, is what Trump says about Canada’s crime and border problem true?

Canada has become a Chinese drug production hub

Called “Wilful blindness: how a network of narcos tycoons and CCP agents have infiltrated the West,” its cover illustrates what Cooper sees as the center of a network of Chinese corruption and crime.   

“The cover shows a graphic photo of Vancouver on a world map with fentanyl pills exploding out of Vancouver going around the world.”  

“Vancouver has become a production hub for China and a trans-shipment hub for fentanyl precursors.”

Cooper says that whilst he is “not pleased with Donald Trump’s rhetoric,” he maintains, “This gets to what Donald Trump is saying.”

“It’s hard for many people to believe that Canada could be put in the same category as Mexico in terms of endangering the United States with fentanyl, illegal immigration and human trafficking,” Cooper says, before adding “…but my research has showed that indeed this is the fear and concern of the U.S. intelligence Community, military and law enforcement.”

Decades of Canadian weakness

How has this happened? Cooper says the problem has been brewing for years.  

“For decades Canada’s weak enforcement against transnational crime weak, and control of borders has allowed international organized crime with linkages to hostile States – most specifically China but also Iran.”

His claims seem astonishing, and yet recent news reports all support his – and Trump’s – conclusions. 

The biggest fentanyl superlab in the world

The top story on the Vancouver Sun today is the discovery of the biggest fentanyl factory in Canadian history. The owner, who is Canadian, did not name the tenants who used his property to build “Canada’s largest ever fentanyl superlab.”

“The Abbotsford man who owns the Falkland property where Canada’s largest-ever fentanyl superlab was discovered in October says he was just the landlord and unaware of what was going on there.”  

David Asher, senior fellow at the Hudson Institute, said it was in fact the largest fentanyl production site in the world, and was certainly linked to “Chinese organized crime.”

Speaking to Rosemary Barton on the Canadian Broadcasting Corporation, Asher explained on February 9, “I think they are sitting on a big scandal here. How many other labs do you think they have going?” 

Asher, who has advised the U.S. State department on countering money laundering and terrorism financing, claimed “there’s very little border enforcement going on” in Canada, dismissing claims by the Canadian media that Canada’s cross-border drug trafficking into the U.S. was insignificant compared to that of Mexican cartels on the U.S. southern border. 

Asher further claims that Mexican cartels are in fact transporting drugs by ship to Canada to be trafficked into the U.S., because “you have almost no port enforcement with police.”

In response to allegations made by the Trump administration that there is a security crisis on the northern border of the U.S., Canada has appointed a “fentanyl Czar,” promised to share more intelligence with the U.S., and said it is stepping up police checks and border controls.  

These measures led to the 30 day “pause” of the threatened tariffs on Canadian trade with the U.S. 

Canadian law is ‘crazy’

So what’s the U.S. government’s problem with Canada?  

Asher praises the federal Royal Canadian Mounted Police (RCMP) but says the problem is Canadian law. Specifically, “The Stinchcombe Law” – a landmark ruling which Asher says means the Canadian police have to inform criminals they are watching them.  

“Basically every time we try to go up on a phone number in Canada almost all the money laundering network is tied to China – and 90% percent of all the money laundering in the United States is tied to Canada.”

“So when we try to go up on those numbers with your police they have to inform the person that we are targeting that we are targeting their number. That’s crazy. How can we run an undercover police operation with your country?”  

Asher explains why claims in the media that low seizure rates of fentanyl from Canada do not give the real story. 

“Which is why we don’t run them. Which is why the seizure statistics are so low. We don’t even try to work with Canada because your laws are distorted.” 

Asher recommends the passing of a RICO act – which he says “I think you’re going to do,” adding this will “solve these problems” in permitting law enforcement to correctly designate these networks as “criminal and racketeering operations” – and as a form of “terrorism.” Asher, together with Cooper, says Iran is also involved in drug trafficking in Canada. 

When asked whether fentanyl and money laundering are the “real reason” for Trump’s threats, Asher said, “yes,” concluding: “Our countries are getting killed by fentanyl. We gotta protect ourselves.”

The Supreme Court of Canada appears to agree, ruling last December that constitutional privacy can be violated to address the national “opioid crisis.”

Massive money laundering operation

Is there any basis in reality for Asher’s claims on the scale of money laundering from Canada? Reports on the actions of the second biggest bank in Canada would suggest there is.  

Last May Canada’s Toronto Dominion (TD) Bank was hit with the largest fine in history for money laundering, initially being ordered to pay around 9 million dollars. 

In October 2024, following an investigation of its U.S. operations, TD Bank agreed to pay 3 billion dollars in fines. It had been found in one case to have “…facilitated over $400 million in transactions to launder funds on behalf of people selling fentanyl and other deadly drugs.”

Reuters reported the bank had “…failed to monitor over $18 trillion in customer activity for about a decade, enabling three money laundering networks to transfer illicit funds through accounts at the bank.” Employees had “openly joked” about the “lack of compliance “on multiple occasions.” 

The Wall Street Journal reported on May 3, 2024 that the U.S. Department of Justice (DOJ) was conducting an “investigation into TD Bank’s internal controls” which “focuses on how Chinese crime groups and drug traffickers used the Canadian lender to launder money from U.S. fentanyl sales.”

Reuters added how TD Bank’s “internal controls” had came under investigation, “since agents discovered a Chinese criminal operation bribed employees and brought large bags of cash into branches to launder millions of dollars in fentanyl sales through TD branches in New York and New Jersey.”  

The charges against Canada are supported by facts presented by people who support and do not support Donald Trump, and the actions of Chinese billionaires and their comfortable relationship with Canadian law have been reported for years.   

Though Trump’s habit of making headline-grabbing threats to secure agreement may be shocking, what is perhaps most shocking of all is to find out the facts behind the headlines are more damning than his description of the problem. Trump’s solution, as Asher outlines, appears not to be “annexation” but the restoration of law and order and the exposure of corruption.

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