Also Interesting
23andMe; The True Meaning of Family
I had seen ads many times on my Facebook feed from 23andme, and I have wanted to do it for a long time. The kits offer ancestry breakdown and personalized health insights which have always intrigued me. After all, from the depths of my core, I believe nothing is more important than family.
My desire to know more might be hard for someone to understand, looking from the outside. My god, some people on the inside don’t understand either. They might ask, “How can someone who professes to love her family be estranged from so many of her family members?” From my perspective, I lost my dad, my mother, my sister, and my brother due to alcoholism even though some of them are still alive.
My mom and dad married just before I was born in 1968. After having my brother and my sister, they divorced when I was eight or nine, due to my father’s problem with alcohol. My brother, Brett, my greatest friend, became another alcoholic branch on our family tree and lost his long courageous battle with addiction and mental illness when he was 39.
I had a relationship with my parents and sister until well into my thirties. Not a perfect one, as relationships within the walls of families can be challenging, but a life that included them. I loved them all very much. Even so, our immediate family unit dissolved under the stresses of my brother’s addiction as well as many unhealthy family patterns and blame-shifting. It all became too much.
My brother alone is responsible for his alcoholism; our reaction to it was never his responsibility. For many reasons, including my wellbeing and that of my husband and my two young sons, I made the painful decision to love my father, mother, and sister from afar. I ceased all contact more than ten years ago.
Through years of therapy, I worked extremely hard to be healthy and happy. I had spent too many decades making poor decisions and looking after other people. Finally, I found the courage to look after the needs of my own family first—my husband and sons. And I am most proud to say that I finally looked after myself; I responded to my own needs. That wasn’t and isn’t selfish. For my own mental health it was necessary.
I have always known my dad’s side of the family came from England, as we are all very close, but my excitement and hope in ordering the 23andme kits was to learn a little more about my mother’s side of the family. Growing up I only ever met my mom’s parents, her sister, and that sister’s children, my two cousins. I never met, nor did my mother ever mention, any of her aunts, uncles, cousins, or even grandparents.
My husband of 30 years, Jim, agreed that it would be amazing to learn more about where our families originated. He knows his family came from England too, whereas I was excited with the possibility of knowing where my mother’s parents came from. I had been close to them, as were my brother and sister, but we lost our grandparents when we were still young. My nana died from dementia complications when I was only 18, and my papa died when I was around 25 or 26. I feel blessed that Papa got to meet and spend time with his two great-grandchildren, Rick and Ryan, before he passed away.
Last November my husband and I opened our kits, filled the little tubes with saliva, and sent them off in the mail. I waited. And waited. And waited some more. I was so eager to get the results, like a kid waiting patiently to open a Christmas present, and I was disappointed when they didn’t update the information on my online portal as quickly as they had originally promised. Finally, the results arrived on January 15, 2022. I was a little sad as the data seemed a little vague. It confirmed that my relatives came from England, yet there wasn’t much other information. I was looking to know more about my nana and papa, maybe something more exotic, but I suppose that is where their families originated too.
So, after looking it over and analyzing my health data I logged out of my 23andme portal and I doubt I ever would have thought more about it or logged in again.
I was at work just a few weeks later, on February 7, when my phone beeped with an email that had a 23andme logo: “Hey Jodee, My name’s James Dodds and 23andme says that we may be half siblings. My dad, Jim Dodds, was from Ponoka so I am wondering if that’s the connection.”
I was completely calm as I read and responded within ten minutes to this unexpected news. I know everyone is different, but for me I have experienced firsthand how my body and mind reacts when being in shock. After all, I remember clearly when two police officers came to my front door in the middle of the night to tell me my brother had taken his own life. When I shared it with my husband that evening and with my two adult sons, now 29 and 31, they didn’t quite comprehend what it could mean. I knew instantly, not because I could have ever imagined such a thing or that there was a hint of some deep dark family secret, because there wasn’t. I live now, as I did as a young child with my parents, very close to Ponoka, Alberta. This wasn’t someone emailing me from halfway across the world, this was 20 minutes away. DNA doesn’t lie.
The initial shock had worn off by that evening. Random visions started going through my mind, causing floods of tears. My fully clothed dad saving me from drowning when I walked off the edge of a pier during a summer vacation when I was probably five years old. My grandma’s face—it sits in a beautiful frame in my office. Big Tisdale Christmas get-togethers with everyone from my dad’s side of the family at my house. My earliest memory of looking inside eggs with a red light with my grandfather when I was three or four. Being the oldest grandchild. Memories and tears. More memories and tears. And finally, my dad’s siblings—Uncle Les, Auntie Myrna, and Auntie Mary—all of whom have stood by me and supported me through my life’s journey. Never, not once, judging or condemning me or taking sides when it came to my complicated relationship with my father. They have loved me unconditionally, while loving their brother too. I LOVE my family.
Along with the tears came the overwhelming sense of disbelief and pain. My heart has been shattered.
My whole life flashed before my eyes. I knew my mother was pregnant when she got married to my father and since the whole marriage wasn’t blissful, we never talked about any other details after they divorced. As I tried to unwrap all my feelings, not knowing whether my mother lied or took her best guess and married my dad, I had no feeling of rage when I texted her: “I would like to know please your connection (and/or relationship with a Jim Dodds). I don’t need a long story. I don’t need contact with you. Just a simple one or two sentence answer. I would appreciate if you could get back to me within a day as this is time sensitive. Thank you.”
I am aware that this would come to her as much of a shock after 53 years as it did to me. But our estrangement complicated matters and her shock isn’t my responsibility. So, once again, I waited. And waited. And waited some more. It seemed like days, but in fact it was the next morning when I received a reply from my mother: “The only Jim Dodds I ever knew, I dated someone with that name when I was 18.”
I was already sure it was true. He is my biological father.
I don’t think anyone would ever blame me if my initial reaction would be hating my mother. You don’t have to be estranged for that. I think to myself even in the closest of families, this surprise revelation could ruin a mother and daughter relationship and cause tremendous upset. I am as imperfect as anyone, but I never react based on hate or anger. I am not even capable of feeling those emotions.
Life is full of twists, turns, losses, happiness, and hardships. I have lived through my fair share of pain, and this is no different. Pain is not a contest. We all experience it, and there are many different reactions. Sadly, often it is human nature when something bad or traumatic happens to be furious or to want to hold someone else responsible. We blame ourselves, we blame others, sometimes people blame god, but following those emotions will only keep us angry, unhealthy, and stuck in the same place. Instead, I always have a deep-seated hope for everyone, regardless of circumstance, to find the strength to follow empathy, compassion, understanding and love because that path leads to peace. Being all of those things never means that you have to accept relationships that are not good for your own health, happiness, and spirit but I never make important life’s decisions based on toxic emotions.
And so, in following with my head and also my heart, I met with my mother, the first time I have seen her face in nine years.
I don’t know the future of the relationship between me and my mom or if there will even be one. Before our visit, a lot of damage had been done that I am unsure can be reversed but I am putting all of that aside for today. As I share this revelation, I stand beside my mother as I believe her when she says there was no ill intent. She had been dating a bull rider, Jim Dodds, and loved him. But she was so young and had already experienced trauma of her own and had a past with my father. They had a daughter together four years before I was born, in 1964, who was given up for adoption. That connection was why my mom started seeing my dad again. And when she got pregnant at 19, she broke things off with Jim, and told him she was getting married without ever mentioning her pregnancy. With her whole heart she believed my dad was my biological father.
I have cried a million tears the last couple weeks, had many sleepless nights, and swam hundreds of lengths at the pool downtown in Sylvan Lake to calm my mind. And what I realized is that family is so much more than being related by blood. It is about being there for each other, through the good times, and especially the bad. It is the relationships in our lives that provide a sense of security and belonging. It is people that hold your heart gently in their hands. It is about feeling you are in a safe space, never worried someone won’t love you, no matter what you share. Family is about feeling valued, respected, and understood. It is about bumps in the road yet creating memories that are built on pure, unconditional love. Family is being able to say you are sorry when someone says you hurt them.
I am incredibly blessed to have so many relationships in my life that provide all these things and more, many of whom are friends that I wholeheartedly consider my family. We live in a beautiful world, where children continue to be adopted, people get divorced and then remarried with blended families, foster parents, surrogacy, and IVF sometimes with anonymous donors. Even same sex couples are fulfilling their dreams of becoming parents. There are many scenarios, and all of those people are no less loved, no less connected and no less family than those that share DNA. I always knew this; it just took a few days to catch my breath.
As much as my dad and I had our own challenges throughout the course of our lives, I loved him very much. This is not a win for me. I never, not once, wished for or longed for a different father. He passed away in February 2018. As much as our own conflicts and estrangement, I think this would have broken his heart.
I am still continuing to process, and my biggest source of pain and disbelief right now, is that my biological father Jim passed away on February 18, 2021, just over a year ago from cancer. He will never know that I was born. We will never get the opportunity to meet and he will never know his amazing grandsons.
There is no regret from me or desire to change the course of any of our lives, because, had my mom, my dad, or Jim Dodds known, the alternative would be worse than what we are all faced to accept today. Any other decision would change the course of so many different lives. Others quite likely would never have been born, such as my newly discovered half-siblings Jaime, James, and Jade as well as the brother I lost ten years ago. So as hard as it is to work through all of my emotions, things worked out as they should.
For me, I would never want to alter the course of fate. I love my family and was always meant to be the sister of Brett Tisdale
Also Interesting
How to Streamline Your Car Sales in Toronto? The Pointer for Car Sellers
Many car owners doubt whether selling their property is worth the hassle they may face during sales. That’s reasonable because a car is not a small item, and you probably spent much on its purchase at some point and regularly invested in it to maintain it in good condition. Then, selling it for pennies is not your choice.
We went ahead and contacted Topcashforcars.ca, a company that is reputed for giving the highest cash prices for cars in Toronto. Their approach is straightforward and reduces hassle for sellers who want to sell their vehicles profitably without the complexities of dealing with customers.
Choosing the Right Counterparty Is a Key to Success
First, have you already decided where and to whom you can sell a vehicle? That’s your #1 thing to do. Typically, the choice is either selling autos to individuals who want to buy a second-market car to save some dollars or to specialized companies engaged in car buying. These companies are diverse enough and they often offer good conditions for a seller although their pricing is diverse too.
How can you get in touch with such buyers?
- For individuals who buy second-hand vehicles, you can search on big Canadian bulletin boards online and sometimes, on social networks.
- For the companies to deal with, Google is your best friend to ask for help. However, our consultants, Topcashforcars.ca also are among these buyers, so you can make it even easier and apply to them.
What is more beneficial for a car seller at this stage? We can surely say that dealing with car-buying companies considerably saves you time. The whole negotiation process can take a couple of hours, so you won’t wait long and remain under pressure of uncertainty.
Making It Lighting-Fast Is Possible
The previous tip leads to another one: you can sell a car in a lighting-fast mode. Just do some easy preps like its examination at the service station to consider what price can you claim for it and clean it up. This takes no more than a day if you have a good service station in your neighborhood and it helps clearly understand the price and the condition of your car.
Then, you can ensure you set a real price by using special online calculators provided by the same car-buying companies. It may take just a couple of minutes and you’ll get a precise calculation based on your vehicle’s type, age, model, condition, and specific features.
Getting Cash Instead of Bank Transfers or Checks Is Faster
One more thing you can do to sell your auto as fast as possible is to sell it for cash. Bank operations often take additional days to be processed. Thus, even if you are lucky enough to get in touch with a good buyer quickly, and even if you conclude a deal in a day or two, it’s not guaranteed that you get money to your bank account similarly quickly. Applying for cash transactions you avoid troubles with banks and extra commissions for the transaction too.
As you can see, selling a vehicle can be eating pears for you if you plan your sale and follow the tips we shared in this article.
If followed, these recommendations can allow you to easily sell your car and make a handsome return in the process. It is even more rewarding because time and energy has become invaluable and cash for cars, Toronto based companies and specifically Topcashforcars.ca, will ensure the vehicle is sold for the best price with little input from the owner. When selling a car, it is ideal to do enough research, plan and choose the right buyers so that the car selling process is fast and efficient.
Also Interesting
New frontiers in prostate cancer treatment with Actinium-225
Prostate cancer is one of the most widespread malignant tumors in men. The pathology is successfully
treated in the first three stages, when the tumor can be removed or destroyed by radiation, but the disease at the metastatic stage becomes incurable. Surgery is usually not performed in such patients, and the main methods of treatment are hormonal and chemotherapy.
At a certain point this treatment stops working. 177Lu-PSMA-617 – Lutetium radiotargeted therapy,
becomes the next stage of treatment. A less common method of radiotargeted therapy is the treatment of prostate cancer with Actinium-225. It allows for a good outcome even in patients who have not responded to Lutetium therapy. In addition, the possibility of combined use of Actinium and Lutetium as part of tandem therapy is being investigated.
Principle of the method
Prostate cancer cells express a protein called prostate-specific membrane antigen (PSMA), which is not found in other tissues. PSMA is a target for the radiopharmaceutical. Once injected into the body, the drug accumulates only in tissues with high levels of PSMA because it binds to this protein. This results in a selective effect on the tumor and its metastases with minimal side effects.
Various radionuclides can be attached to ligands that target PSMA. The first such radionuclide was
Lutetium-177, which was synthesized in Germany in 2010, and its efficacy was first confirmed in trials in 2015. The good results were subsequently confirmed in a large study involving 13 university hospitals in Germany.
In recent years, Actinium-225 has been used instead of Lutetium. It destroys cancer cells with alpha
radiation.
Advantages and disadvantages of Actinium-225
Lutetium-177 is still considered the mainstay of radiotargeted therapy for castration-resistant prostate
cancer. However, Actinium is also used in certain situations, usually in patients with advanced cancer who have not responded to Lutetium treatment or when the efficacy of 177Lu-PSMA-617 has decreased after several courses (cancer progression has resumed).
Advantages of Actinium-225 over Lutetium-177:
● More pronounced effect due to alpha radiation causing double-strand breaks in DNA strands
● Less toxic effect on bone marrow and hematopoietic function due to shorter recovery time
● Works even in cases where the cancer is progressing against the background of Lutetium therapy
However, it is worth considering the disadvantages of this method:
● Limited evidence base compared to Lutetium
● Higher incidence of side effects, especially dry mouth
Who is a candidate for Actinium therapy
Radiotargeted therapy with Actinium is considered a novel treatment. The technique is indicated for
patients with metastatic castration-resistant prostate cancer (MCRPC) who:
● Have received Lutetium radiotargeted therapy but have not responded to it
● Have responded to Lutetium radiotargeted therapy, but have stopped responding after several
courses of treatment
● As part of tandem therapy: when Actinium and Lutetium are used in reduced doses
In summary, Actinium therapy is one of the last treatment options. It is used when chemotherapy, hormone therapy, radiotargeted therapy with Lutetium, and possibly targeted therapy (in the case of BRCA mutations, which occur in 28% of patients with metastatic prostate cancer) have already been tried. In addition, the choice of treatment tactics takes into account the location of the metastases. In the presence of predominantly bone metastases and pain syndrome, radionuclide therapy with Radium-223 is preferred, and in the presence of predominantly organ metastases, radiotargeted therapy with Lutetium or Actinium is performed.
If you want to undergo innovative treatment in Germany, visit Booking Health website. Our team will find a clinic for you and organize your trip.
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